Electric Shock: How Electricity
Could Be The Key To Human Regeneration. by Cynthia Graber. Matter, Kindle, $0.99
The dystopic science fiction author
Richard K. Morgan writes stories of regeneration taken to the limit.
In his Takeshi Kovacs series, the wealthy or otherwise privileged among humankind
(or post-humans) continuously download consciousness –memories, knowledge,
personality, everything that makes a self – into hardened storage that
can be transplanted from body to newly produced body. Among much else, these books are meditations on immortality
and its discontents, for in Kovacs’ universe, there is death – when one’s body
or “sleeve” ceases to function – and the “real death” that occurs when that encapsulated
solid-state self gets annihilated.
It’s a complicated dream, this vision in which minds persist in infinitely
renewable (and/or interchangeable) bodies.
In 21st century science,
the ambition is a little more grounded; scientists studying the regeneration of
organs, tissues and body parts can be said to suffer amphibian-envy. As Cynthia Graber writes at the start
of Electric Shock, “the axolotl, or
Mexican salamander, has the ability to regenerate everything from its limbs and
tail to its spinal chord and skin…”* Humans? Not so much:
livers and skin can (partly) replace themselves, and children below the age of
twelve, Graber writes, can rebuild fingertips they might be unlucky enough to
lose.
Thus the premise for Graber’s
story: what if it were possible to discover
how to rebuild much more of the human body at any point in its lifecycle? Or rather – what if someone out there
right now thinks he can make that happen, and soon?
What follows is an elegant bending
of a very familiar genre, the common magazine trope of the scientist –
profile. Graber traces the career
of biologist Michael Levin from his émigré childhood to his current pursuit of an off-center approach to the problem of mammalian (target: human)
regeneration. Where almost all the
attention in the engineering of human tissue has focused on
questions of
genetics and – at the cellular level – on the manipulation of stem cells. Such approaches have had their successes, but if the goal is to tell some tissue to “become
an arm” then, Levin's story argues, something else is required.
That something else is the stuff of
Dr. Frankenstein’s dreams: manipulation of the electrical signaling that takes place in every cell in the
body. Graber follows the
conventions of profile-writing by taking her readers through a quick tour of Levin’s
early life. We learn he was born in Moscow,
brought by his parents to Lynn, Massachusetts at the age of nine, and early
showed talent for computers and fascination with the living world. The catalyst for a life’s work came for
Levin at 17, when he chanced upon a book called The Body Electric, written by Robert Becker, a surgeon with an
unorthodox streak (to put it kindly).
The book had its excesses, but
Levin responded immediately to its reports of lost experiments that had played with electric currents to spark regeneration in marine
animals. During his Ph.D work, he
seemed to outward appearance to have returned to more conventional biological interests, performing significant experiments
on the genetics and biochemistry of development. But once ensconsed in his own lab, Graber writes, Levin returned
to the question of bioelectric signals and the possibility, ultimately, that he
could persuade a human arm or eye grow back.
The balance of Graber’s text –
roughly the last half – tells what Levin has been able to achieve so far, from
growing a four headed flatworm (its own bridge game!) to experiments – still in
progress – through which Levin and his collaborators now hope to persuade a
mouse finger to grow, replacing an amputated digit. The most riveting moment in Graber’s account isn’t that one,
though. That falls to Levin’s colleague Dany Adams, who discovered (and partly stumbled upon) a
technique for mapping the sequence of electrical signals in cells that map the
structure to be developed before that structure begins to form.
Graber’s science writing chops show
up here as she manages to convey both the vivid
sense of the moment and the explanation of what her readers glimpse in their
minds’ eyes. At the same time she
gently – perhaps too much so – points to the big question that (this account,
at least) of Levin’s work leaves unanswered: what is the mechanistic role bioelectric signaling plays
in a sequence of events that
ends at “eye” or “digit.”
That hints at the one gap I found
in Electric Shock. Levin’s work, Graber
told me, is viewed as solid, excellent science by the small community that
works on bioelectric questions But
Graber’s account
does not return to the question she raises at the beginning,
on the interplay between Levin’s view of the body electric and the genetic and
cellular processes involved in building new tissues,
organs, parts. I grasped Levin’s drive, his pursuit, and his impressive record
of successful experiments from this text.
I didn’t get that last step, at least not explicitly: how Levin’s off-the-beaten-path
approach to regeneration fits into the larger corpus of work on the ways
organisms build bodies.
That’s a lot to ask of a relatively
brief text, of course, and to be clear, I don’t think either that Graber should
have written a tome on developmental biology, nor that Electric Shock fails to deliver on its core promise of a gripping
story about science told through the life of one passionate scientist.
But what lifts Electric Shock out of the common run of profiles, is the use Graber
makes of the license given her by the fact of e-publication as opposed to a dead-tree assignment. As Virginia
Hughes wrote in this space recently, not all feature stories benefit from
the elbow room e-published non-fiction novellas offer.
Graber's text does, going long to reach through the biographic
narrative into the sophisticated ideas behind Levin’s work, and thus welcoming its
readers to enter into the arguments his experiments seek to test. But the insight thus gained evokes
more questions, the desire to got yet another step into the inquiry. That’s a good result – recall the show
business adage to always leave the punters wanting more – but there’s a tricky side to this intermediate
length: it’s not always easy to
see whether you’ve finished the job.
With that caveat – hell, I’ll even
cop to a quibble -- the bottom line remains. It's a long leap from evoking a mouse digit to the dreams (or nightmares) of science fiction. But the fascination with the possibility of mastering life's processes -- maybe even the whiff of making mortalitiy malleable -- is common to both. Electric Shock tells the real story of where that curiousity may lead, the one that's happening now, in a finely wrought account of an intriguing figure. And all for a price that leaves you change out of a buck!
*Full disclosure:
the piece was edited by my MIT and Download the Universe colleague Seth Mnookin.
Images: Leonardo da Vinci, Vitruvian Man, 1492, and Studies of Embryos, 1510-1513.
Tom Levenson writes books (most recently Newton and the Counterfeiter) and makes films, about science, its history, and whatever else catches his magpie's love of shiny bits. His work has been honored by a Peabody, a National Academies Science Communication and an AAAS Science Journalism Award, among others. By day he professes science writing at MIT.